apolipoprotein c3 gene polymorphisms are not a risk factor for developing non-alcoholic fatty liver disease: a meta-analysis

conclusions our meta-analysis, while not ruling out possible publication bias, showed no association between gene polymorphisms of apoc3 and the risk of nafld development in different populations in the world. evidence acquisition we performed a meta-analysis of all relevant studies published in the literature. a total of 115 clinical trials or reports were identified, but only seven trials met our inclusion criteria. a meta-analysis was performed according to the cochrane reviewers’ handbook recommendations. results five hospital-based and two population-based case-control studies were included in the final analysis. the overall frequency of apoc3 gene polymorphisms was 67.5% (1177/1745) in nafld and 68.8% (988/1437) in controls. the summary odds ratio for the association of gene polymorphisms of apoc3 and the risk of nafld was 1.03 (95% ci: 0.89-1.22),which was not statistically significant (p > 0.05). context our objective was to evaluate the effect of gene polymorphisms of apolipoprotein c3 (apoc3) on the development of non-alcoholic fatty liver disease (nafld) in different populations.